I've also had a great "out of box" experience with Mint 6. I'm just using the regular gnome desktop that comes on the default install. All hardware works with the exception of the front microphone (the one on the wrist rest area). I have fooled with all the settings I can find, and although the microphone picks up sound and outputs it to the speakers, it will not let me record sounds using the built in "sound recorder" or with audacity. Using a microphone with the microphone jack works fine.
The VGA out works with my old 14" CRT monitor. But you need to set the screen resolutions to the same (800 X 600 is the highest common resolution) for both monitors. Otherwise, the screens are messed up. Also check the box to "mirror" the screens. The only problem I still have is that when I try to reset the S10's screen to 1024 X 600 (default) resolution, the screen will show only a black background and the cursor (which still moves) but no icons or menus. To get back to a working 1024 X 600 resolution, I had to ctrl-alt-F3, followed by a ctrl-alt-delete to restart. (If that still does not work, do the same and select "failsafe" start up, then arrow down to the bottom entry (restores a backup of your xorg.conf) and you are back up running again.
As for everything else, it all "just works". Sound, headphone jack, WIFI, video, card reader, touchpad, webcam, the wireless card physical switch, even the Fn key with screen bright/dim, volume up/down, PrtSc, NmLk keys. I'm impressed! I haven't had a troublefree Linux experience this good with a laptop ever!!
The only thing I am unsure about is the ExpressCard slot. I don't have any ExpressCard devices to try it out.
White Lenovo S10 with 2 GB RAM, Bluetooth,
Supertalent UltrDrive 32 GB SSD w/ Windows 7